Currently available clocks in
EstimAge are listed in the Table below, with accompanying tissue, age range of applicability, training technology, reference.
We encourage authors to submit novel, peer reviewed, software-equipped clocks to our webservice via the contact page.
| Name |
Tissue§ |
Life Phase§§ |
Technology |
Publication |
| Multi-Tissue (Years) | | | |
| EPM | Tissues; D014024 | lifespan | HM450 | Snir et al., 2019 |
| Horvath13 | Tissues; D014024 | lifespan | HM27, HM450 | Horvath, 2013 |
| PhenoAge | Tissues; D014024 | adult | HM450, HMEPIC | Levine et al., 2018 |
Zhang19.blupred
Zhang19.enpred | Tissues; D014024 | lifespan | HM450, HMEPIC | Zhang et al., 2019 |
| Tissue-specific (Years) | | | |
| CorticalClock | Prefrontal Cortex; D017397 | lifespan | HM450, HMEPIC | Shireby et al., 2020
|
| Hannum13 | Blood; D001769 | adult | HM450 | Hannum et al., 2013
|
| Horvath18 | Blood; D001769
Endothelial cells; D042783
Mouth Mucosa; D009061
Saliva; D012463
Skin; D012867 | lifespan | HM450, HMEPIC | Horvath et al., 2018
|
| MEAT | Muscle, Skeletal; D018482 | adult | HM27, HM450, HMEPIC | Voisin et al., 2020
|
| PedBE | Mouth Mucosa; D009061
| pediatric | HM450, HMEPIC | McEwen et al., 2020
|
| Gestational (Weeks) | | | |
| Bohlin16 | Fetal Blood; D005312 | foetal | HM450 | Bohlin et al., 2016
|
| Knight16 | Fetal Blood; D005312 | foetal | HM27, HM450 | Knight et al., 2016
|
Lee19.RPC
Lee19.CPC
Lee19.rRPC | Placenta; D010920 | foetal | HM450 | Lee et al., 2019 |
| Mayne17 | Placenta; D010920 | foetal | HM27, HM450 | Mayne et al., 2017 |
| Forensic Applications (Years) | | | |
| FAradas16 | Blood; D001769 | adult | HM450, EpiTYPER* | Freire-Aradas et al., 2016 |
| ZPiekarska15 | Blood; D001769 | lifespan | Bisulfite conversion+
pyrosequencing assays** | Zbieć-Piekarska et al., 2015 |
| Miscellaneous non-years counting clocks (Cell Cycles, kilobases) | | | |
| EpiTOC° | Neoplasms; D009369 | adult | HM450 | Yang et al., 2016
|
| MiAge° | Neoplasms; D009369 | adult | HM450 | Youn and Wang, 2018
|
| DNAmTL°° | Blood; D001769 | adult | HM450, HMEPIC | Lu et al., 2019
Table. List of EstimAge available clocks. §MeSH: MeSH heading; Unique ID. §§Pediatric 0-18; Adult 18-80. °Mitotic clock (mitotic age=total number of lifetime cell divisions). °°Telomere length clock. *Based on the following CpGs: ELOVL2_C7, C1orf132_C1, TRIM59_C7, KLF14_C1, FHL2_C2. **Based on the following CpGs: CR_1_CpG_9, CR_2_CpG_3, CR_4_CpG_27.28.29, CR_12.1_CpG_3, CR_13_CpG_2, CR_21_CpG_11, CR_23_CpG_3.
|
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